During the summer of 1874, Smetana began to lose his hearing, and total deafness soon followed; he described the gradual, but rapid loss of his hearing in a letter of resignation to the director of the Royal Provincial Czech Theatre, Antonín Čížek. In July 1874 he began hearing anomalous noise and then a permanent buzzing. Not long after the onset he was unable to distinguish individual sounds. At the beginning of October he lost all hearing in his right ear, and finally on 20 October in his left. His treatment was based on maintaining isolation from all sounds, but was unsuccessful. In the weeks following his hearing loss, Smetana composed, arguably his most enduring piece of music, the symphonic poem, The Moldau.
Source: Wikipedia

